Sr. Bonin et al., TREATMENT-RELATED MYELODYSPLASTIC SYNDROME FOLLOWING ABDOMINOPELVIC RADIOTHERAPY FOR ENDOMETRIAL CANCER, Gynecologic oncology, 57(3), 1995, pp. 430-432
A patient with grade II endometrial adenocarcinoma underwent TAH/BSO.
The tumor penetrated 50% of the myometrium. A lesion from the serosa o
f the sigmoid colon was removed and contained metastatic adenocarcinom
a. Metastatic tumor was also found in the common iliac lymph nodes. Po
stoperatively the patient was treated with abdominopelvic radiotherapy
to 30 Gy. The pelvis was boosted to a dose of 46.2 Gy. The vaginal ap
ex was then treated with three applications of high-dose-rate brachyth
erapy to a total dose of 12 Gy. The patient was doing well with no evi
dence of recurrence 52 months following treatment when she was diagnos
ed with a myelodysplastic syndrome. Cytogenetic analysis revealed aber
rations of chromosomes 5 and 7, which is highly suggestive of a treatm
ent-related process. Myelodysplasia induced by radiotherapy alone is a
n unusual but recognized event. (C) 1995 Academic Press, Inc.