TREATMENT-RELATED MYELODYSPLASTIC SYNDROME FOLLOWING ABDOMINOPELVIC RADIOTHERAPY FOR ENDOMETRIAL CANCER

A patient with grade II endometrial adenocarcinoma underwent TAH/BSO. The tumor penetrated 50% of the myometrium. A lesion from the serosa o f the sigmoid colon was removed and contained metastatic adenocarcinom a. Metastatic tumor was also found in the common iliac lymph nodes. Po stoperatively the patient was treated with abdominopelvic radiotherapy to 30 Gy. The pelvis was boosted to a dose of 46.2 Gy. The vaginal ap ex was then treated with three applications of high-dose-rate brachyth erapy to a total dose of 12 Gy. The patient was doing well with no evi dence of recurrence 52 months following treatment when she was diagnos ed with a myelodysplastic syndrome. Cytogenetic analysis revealed aber rations of chromosomes 5 and 7, which is highly suggestive of a treatm ent-related process. Myelodysplasia induced by radiotherapy alone is a n unusual but recognized event. (C) 1995 Academic Press, Inc.