A. Haberal et al., COMPARISON OF MICROSURGERY AND CYANOACRYLATE FOR TUBAL ANASTOMOSIS - AN EXPERIMENTAL-STUDY IN THE RAT, Journal of gynecologic surgery, 12(4), 1996, pp. 261-265
We compared the results of tubal anastomosis performed by a microsurgi
cal technique and by the application of cyanoacrylate, a tissue adhesi
ve agent. Forty Spraque-Dawley female rats were reared under identical
conditions and divided into four groups of 10 rats each. In the first
group, all the rats underwent a lower midline vertical incision follo
wed by closure of the abdomen using 3-0 Vicryl. In the second group, a
nastomosis of the left uterine horn was performed by using cyanoacryla
te. The right horn was anastomosed microsurgically with 8-0 Prolene su
tures. In the third group, the uterine horn was anastomosed with cyano
acrylate, and the left horn was ligated. In the fourth group, the righ
t horn was anastomosed by microsurgical technique, and the left horn w
as ligated. After mating, a repeat laparotomy was performed to evaluat
e the number of pregnancies, the presence and severity of adhesion for
mation, and histopathologic changes induced by both techniques. Althou
gh there was no difference between the two methods with respect to cor
pus luteum formation in the ovaries and the number of embryos, the num
ber of pregnancies was higher when microsurgical techniques were used.
The severity of adhesion formation was greater after cyanoacrylate ap
plication than after microsurgery, and this could be the reason for th
e higher pregnancy number in the microsurgery group. Cyanoacrylate app
lication is a simple and time-saving procedure. Based on these finding
s in the rat, a prospective trial in the human would be warranted. Thi
s may be an alternative to microsurgery in tubal end-to-end anastomosi
s.