COMPARISON OF MICROSURGERY AND CYANOACRYLATE FOR TUBAL ANASTOMOSIS - AN EXPERIMENTAL-STUDY IN THE RAT

We compared the results of tubal anastomosis performed by a microsurgi cal technique and by the application of cyanoacrylate, a tissue adhesi ve agent. Forty Spraque-Dawley female rats were reared under identical conditions and divided into four groups of 10 rats each. In the first group, all the rats underwent a lower midline vertical incision follo wed by closure of the abdomen using 3-0 Vicryl. In the second group, a nastomosis of the left uterine horn was performed by using cyanoacryla te. The right horn was anastomosed microsurgically with 8-0 Prolene su tures. In the third group, the uterine horn was anastomosed with cyano acrylate, and the left horn was ligated. In the fourth group, the righ t horn was anastomosed by microsurgical technique, and the left horn w as ligated. After mating, a repeat laparotomy was performed to evaluat e the number of pregnancies, the presence and severity of adhesion for mation, and histopathologic changes induced by both techniques. Althou gh there was no difference between the two methods with respect to cor pus luteum formation in the ovaries and the number of embryos, the num ber of pregnancies was higher when microsurgical techniques were used. The severity of adhesion formation was greater after cyanoacrylate ap plication than after microsurgery, and this could be the reason for th e higher pregnancy number in the microsurgery group. Cyanoacrylate app lication is a simple and time-saving procedure. Based on these finding s in the rat, a prospective trial in the human would be warranted. Thi s may be an alternative to microsurgery in tubal end-to-end anastomosi s.