THIOALKYL DERIVATIVES OF VITAMIN-K-3 AND VITAMIN-K3-OXIDE INHIBIT GROWTH OF HEP3B AND HEPG2 CELLS

Authors
KERNS J NAGANATHAN S DOWD P FINN FM CARR B
Citation
J. Kerns et al., THIOALKYL DERIVATIVES OF VITAMIN-K-3 AND VITAMIN-K3-OXIDE INHIBIT GROWTH OF HEP3B AND HEPG2 CELLS, Bioorganic chemistry, 23(2), 1995, pp. 101-108
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology
Journal title
Bioorganic chemistry → ACNP
ISSN journal
00452068
Volume
23
Issue
2
Year of publication
1995
Pages
101 - 108
Database
ISI
SICI code
0045-2068(1995)23:2<101:TDOVAV>2.0.ZU;2-V
Abstract
A new hypothesis regarding the effect of vitamin K-3 On hepatoma cell growth is presented. In brief, exploration of cell growth activity has been identified with the action of p34(cdc2) kinase and its associate d protein tyrosine phosphatase. After exploring a series of substitute d derivatives of vitamin K and vitamin K-3 oxide, we suggest a mechani sm involving alkylation at the active-site cysteine for the inhibition of the protein tyrosine phosphatase which controls the activity of th e p34(cdc2) kinase. (C) 1995 Academic Press, Inc.