RANDOMIZED DOUBLE-BLIND-STUDY COMPARING THE EFFICACY OF TERAZOSIN VERSUS PLACEBO IN WOMEN WITH PROSTATISM-LIKE SYMPTOMS

Purpose: We attempt to determine whether terazosin is effective therap y for the treatment of prostatism-like symptoms in women. Materials an d Methods: A total of 29 women 47 to 79 years old with prostatism-like symptoms entered a randomized double-blind study comparing terazosin (14) versus placebo (15). The salient inclusion and exclusion criteria consisted of an American Urological Association (AUA) symptom score o f 8 or more, post-void residual volume less than 300 ml. and absence o f stress urinary incontinence. Results: The baseline and final visit A UA symptom scores were 12.7 and 10.7, respectively, in the placebo gro up, and 16.4 and 13.6, respectively, in the terazosin group. The diffe rences between the change in AUA symptom score in the placebo and tera zosin groups were not clinically or statistically significant. Conclus ions: Our study demonstrates that terazosin is not effective for the t reatment of prostatism-like symptoms in aging women.