H. Lepor et C. Theune, RANDOMIZED DOUBLE-BLIND-STUDY COMPARING THE EFFICACY OF TERAZOSIN VERSUS PLACEBO IN WOMEN WITH PROSTATISM-LIKE SYMPTOMS, The Journal of urology, 154(1), 1995, pp. 116-118
Purpose: We attempt to determine whether terazosin is effective therap
y for the treatment of prostatism-like symptoms in women. Materials an
d Methods: A total of 29 women 47 to 79 years old with prostatism-like
symptoms entered a randomized double-blind study comparing terazosin
(14) versus placebo (15). The salient inclusion and exclusion criteria
consisted of an American Urological Association (AUA) symptom score o
f 8 or more, post-void residual volume less than 300 ml. and absence o
f stress urinary incontinence. Results: The baseline and final visit A
UA symptom scores were 12.7 and 10.7, respectively, in the placebo gro
up, and 16.4 and 13.6, respectively, in the terazosin group. The diffe
rences between the change in AUA symptom score in the placebo and tera
zosin groups were not clinically or statistically significant. Conclus
ions: Our study demonstrates that terazosin is not effective for the t
reatment of prostatism-like symptoms in aging women.