DETERMINATION OF THE STEREOCHEMISTRY OF SUBSTITUTED 4-(SULFOAMIDOALKYL AND SULFONAMIDOALKYL)PIPERIDINE-2-CARBOXYLIC ACIDS WITH H-1-NMR, COSY, AND HOMONUCLEAR NOE EXPERIMENTS

Authors
ELHADRI A THOMASSON F LECLERC G
Citation
A. Elhadri et al., DETERMINATION OF THE STEREOCHEMISTRY OF SUBSTITUTED 4-(SULFOAMIDOALKYL AND SULFONAMIDOALKYL)PIPERIDINE-2-CARBOXYLIC ACIDS WITH H-1-NMR, COSY, AND HOMONUCLEAR NOE EXPERIMENTS, Spectroscopy letters, 28(5), 1995, pp. 795-803
Citations number
10
Categorie Soggetti
Spectroscopy
Journal title
Spectroscopy letters → ACNP
ISSN journal
00387010
Volume
28
Issue
5
Year of publication
1995
Pages
795 - 803
Database
ISI
SICI code
0038-7010(1995)28:5<795:DOTSOS>2.0.ZU;2-5
Abstract
Basically the aim of this work is to define the accurate configuration of 4-substituted (sulfo- and sulfonamidoalkyl) piperidine-2-carboxyli c acids which have been conceived as potential NMDA antagonists. H-1 N MR and 2D NMR (COSY) followed by qualitative Homonuclear NOE have led to the assignement of the (+/-) cis and (+/-) trans configuration of t he whole family's compounds.