DEVELOPMENT OF PLAQUE AND GINGIVITIS AFTER MOUTHRINSING WITH 0.2-PERCENT DELMOPINOL HYDROCHLORIDE

A double-blind, randomized, 2-wk experimental gingivitis clinical tria l with cross-over design in 14 dental students was conducted in order to study the efficacy and safety of delmopinol hydrochloride solution (2 mg/ml), used with no other oral hygiene procedures, in comparison w ith placebo. Plaque formation was measured by the QUIGLEY & HEIN Plaqu e Index and gingivitis was assessed by bleeding on probing according t o MUHLEMANN & SON. Rinsing with delmopinol resulted in lower plaque sc ores compared to placebo. The development of gingivitis was weak durin g the 2-wk test periods, and thus no conclusive results were obtained. As in previous studies, the most frequent adverse event when rinsing with delmopinol was a transient anaesthetic sensation in the oral muco sa, The results showed that rinsing with delmopinol hydrochloride solu tion (2 mg/ml) for 60 s twice daily with no other oral hygiene procedu res led to less plaque formation than rinsing with placebo. This study also showed good tolerance and acceptability of mouthrinsing with del mopinol.