IMIDAZO[1,2-B]PYRIDAZINES .18. SYNTHESES AND CENTRAL-NERVOUS-SYSTEM ACTIVITIES OF SOME 6-(CHLORO AND METHOXY)IMIDAZO[1,2-A]PYRIDINE, 7-(CHLORO AND METHOXY)IMIDAZO[1,2-A]PYRIDINE AND 8-(CHLORO AND METHOXY)IMIDAZO[1,2-A]PYRIDINE ANALOGS

Syntheses are reported for some 2-aryl-3-(benzamidomethyl and methoxy) -6(7 and 8)-chloro-and 6(and 8)-methoxy-imidazo[1,2-a]pyridines. In te sts of the ability of these compounds to displace [H-3]diazepam from r at brain membrane, those with g-chloro and 6-methoxy groups bound most strongly, and relatively small differences only were observed between corresponding imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines.