ETATO)AMMINEDICHLORO(CYCLOHEXYLAMINE)PLATINUM(IV), AN ORALLY-ACTIVE ANTICANCER DRUG

Authors
NEIDLE S SNOOK CF MURRER BA BARNARD CFJ
Citation
S. Neidle et al., ETATO)AMMINEDICHLORO(CYCLOHEXYLAMINE)PLATINUM(IV), AN ORALLY-ACTIVE ANTICANCER DRUG, Acta crystallographica. Section C, Crystal structure communications, 51, 1995, pp. 822-824
Citations number
11
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
51
Year of publication
1995
Part
5
Pages
822 - 824
Database
ISI
SICI code
0108-2701(1995)51:<822:EAOA>2.0.ZU;2-C
Abstract
The structure of the anticancer drug tato)-amminedichloro(cyclohexylam ine)platinum(IV), [PtCl2-(C2H3O2)(2)(C6H13N)(NH3)], is reported. The a cetato groups are axial to the square plane composed of the chlorine a nd amine substituents. The cyclohexane ring may sterically hinder one of the acetato groups for metabolic attack. The amine groups are hydro gen bonded to the carbonyl O atoms of the acetato groups.