Background: Pneumatic retinopexy is a procedure for reattaching the re
tina by injecting an expanding gas bubble and using either laser or cr
yopexy. The procedure is controversial because there may be a lower in
itial success rate, and intraocular gas may increase the risk of proli
ferative vitreoretinopathy. Methods: The authors performed a retrospec
tive review of 107 unpublished consecutive cases of pneumatic retinope
xy together with a literature review of 25 statistical series with pri
mary attention to failures. Univariate and multivariate analyses were
carried out on the data set, and adjusted odds ratios for risk factors
associated with failure were calculated using logistic regression. Re
sults: Initially, 74 (69%) of 107 patients had successful results, and
with reoperations the success rate increased to 98%. Failure of the p
rocedure to achieve retinal reattachment occurred soon after the initi
al procedure, with 86% of recorded failures occurring within the first
month. The initial cause of failure was new or missed breaks in 14.9%
, reopened initial breaks in 11.2%, and breaks never closed in 4.6%. R
isk factors that showed a correlation with failure were patients being
male (adjusted odds ratio = 2.65), eyes with preoperative visual acui
ty worse than 20/50 (adjusted odds ratio = 1.21), eyes with four quadr
ants of retina[ detachment or total detachment (adjusted odds ratio =
2.03), aphakic or pseudophakic eyes (adjusted odds ratio = 1.91), and
eyes with additional pathologic findings (adjusted odds ratio = 3.14).
Poor visual outcome was associated with initial visual acuity less th
an 20/50 (adjusted odds ratio = 15.7) and eyes with four quadrants of
retina[ detachment or total detachment (adjusted odds ratio = 5.01). C
onclusions: Failures of pneumatic retinopexy occur early in the postop
erative course. Factors known to be associated with failure of retinal
reattachment using scleral buckling also were associated with failure
in pneumatic retinopexy. A higher success rate in females was noted,
suggesting that educational efforts may need to be greater in males. P
oorer visual results occurred in patients with poor initial vision and
in eyes with four quadrants of retinal detachment or total detachment
s