THE ISOLATION AND STRUCTURAL ELUCIDATION OF 3 NEW NEOLIGNANS, PUBERULIN-A, PUBERULIN-B, AND PUBERULIN-C, AS PLATELET-ACTIVATING-FACTOR RECEPTOR ANTAGONISTS FROM PIPER-PUBERULUM

Authors
ZHANG SX CHEN K LIU XJ ZHANG DC TAOWIEDMANN TW LEU SL MCPHAIL AT LEE KH
Citation
Sx. Zhang et al., THE ISOLATION AND STRUCTURAL ELUCIDATION OF 3 NEW NEOLIGNANS, PUBERULIN-A, PUBERULIN-B, AND PUBERULIN-C, AS PLATELET-ACTIVATING-FACTOR RECEPTOR ANTAGONISTS FROM PIPER-PUBERULUM, Journal of natural products, 58(4), 1995, pp. 540-547
Citations number
22
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
58
Issue
4
Year of publication
1995
Pages
540 - 547
Database
ISI
SICI code
0163-3864(1995)58:4<540:TIASEO>2.0.ZU;2-J
Abstract
Three new neolignans, puberulins A [1], B [2], and C [3], were isolate d from Piper puberulum. Their structures and relative stereochemistrie s were determined from spectral data and the X-ray crystallographic an alysis of 1. Compounds 1 and 3 inhibit specific platelet activating fa ctor receptor binding with IC50 values of 7,3 and 5.7 mu M, respective ly.