STUDIES ON STEROIDAL PLANT-GROWTH REGULAT OR .31. EFFECTS OF METHANESULFONAMIDE ON THE ASYMMETRIC OSMYLATION OF (22E) - STEROIDAL UNSATURATED SIDE-CHAINS

Authors
HUANG LF HU QY ZHOU WS XIA LJ BI MH
Citation
Lf. Huang et al., STUDIES ON STEROIDAL PLANT-GROWTH REGULAT OR .31. EFFECTS OF METHANESULFONAMIDE ON THE ASYMMETRIC OSMYLATION OF (22E) - STEROIDAL UNSATURATED SIDE-CHAINS, Huaxue xuebao, 53(5), 1995, pp. 501-508
Citations number
29
Categorie Soggetti
Chemistry
Journal title
Huaxue xuebao → ACNP
ISSN journal
05677351
Volume
53
Issue
5
Year of publication
1995
Pages
501 - 508
Database
ISI
SICI code
0567-7351(1995)53:5<501:SOSPRO>2.0.ZU;2-7
Abstract
The effects of methanesulfonamide on the asymmetric osmylation of (22E )-steriodal unsaturated sidechains have been studied with six examples , MeSO(2)NH(2) can greatly enhance the rate of dihydroxylation in case there is another Delta(2(3)) double bond without effect of the enanti oselectivity. However, the rate of reaction and stereoselectivity are decreased, the amounts of chiral ligand and osmium catalyst being dimi nished. Our improved method is very effective to construction of brass inosteroidal sidechains with DHQD-PHN and DHQD-NAP as chiral ligands.