Cg. Fichtner et al., HYPODENSITY OF PLATELET SEROTONIN UPTAKE SITES IN POSTTRAUMATIC-STRESS-DISORDER - ASSOCIATED CLINICAL-FEATURES, Life sciences, 57(2), 1995, pp. 37-44
Citations number
63
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
We have previously reported that binding to blood platelets of paroxet
ine, a selective serotonin (5-HT) reuptake inhibitor which binds to 5-
HT uptake sites, is decreased in patients with posttraumatic stress di
sorder (PTSD). Specifically, we found a lower number of platelet H-3-p
aroxetine binding sites (B-max) and a lower dissociation constant (K-d
) for H-3-paroxetine binding in combat veterans with PTSD compared to
normal control subjects. In the current study we assessed the relation
ship of platelet H-3-paroxetine binding to clinical features in 41 Vie
tnam combat veterans with SCID-diagnosed PTSD. The results indicated t
hat B-max of platelet H-3-paroxetine binding was negatively correlated
with both state and trait anxiety, as well as with depressive and ove
rall PTSD symptoms. However, there was no evidence that platelet H-3-p
aroxetine binding differed as a function of comorbid psychiatric diagn
oses including major depression, other anxiety disorders, and substanc
e abuse in these patients.