This study investigated the relationship between Santa Ana wind condit
ions and visits for asthma at a southern California emergency departme
nt. Visits to the emergency department for asthma were analyzed retros
pectively to determine whether the incidence increased during Santa An
a wind conditions. These northeasterly winds are common during fall an
d winter in southern California and belong to a class known as Foehn w
inds. They are characterized by gusty winds, decreased relative humidi
ty, warm temperatures, and decreased levels of airborne pollutants. Du
ring a 4-year period, we noted that emergency department visits for as
thma increased (3.12 vs. 2.16 visits per day, P <0.0001) during Santa
Ana winds compared with other weather conditions. Asthmatics presentin
g during Santa Ana winds appeared to be more ill, as judged by higher
admission rates (21.9 vs. 18.7%, P <0.05). These winds were also assoc
iated with reduced particulate matter (PM10) counts (P <0.0001). Altho
ugh the magnitude of the increase in emergency department visits was s
mall, it occurred at a time when typical inciters of respiratory disea
se should be minimal. An as yet unidentified factor associated with th
ese winds may be a stimulant for some asthmatics. Similar wind pattern
s in other localities might affect respiratory disease as well.