EXPERIMENTAL APPROACHES TO THERAPY AND PROPHYLAXIS FOR HEAT-STRESS AND HEATSTROKE

New developments in the fields of biochemistry, physiology, sepsis, ca ncer therapy, and molecular genetics have led to opportunities for the development of new therapies and prophylaxes for heat illnesses and f or improving human performance during conditions of environmental stre ss. These include antilipopolysaccharide ride agents, anticytokines, p otassium channel agents, a diet rich in omega-3 fatty acids, and psych ological conditioning. This review summarizes the backgrounds and rece nt findings in the above fields and provides specific suggestions for potential therapy and prophylaxis for classic and exertional heatstrok e and for improving athletic performance.