OLIGOCLONAL BETA-GALACTOSIDE-SPECIFIC GAMMA-IMMUNOGLOBULINS ALLOW THEIMMUNOCYTOCHEMICAL DETECTION OF CELLULAR ANTIGENIC DETERMINANTS EXPRESSED IN MOUSE-BRAIN AFTER SURGICAL INJURY

Histological brain sections were probed with human oligoclonal lectin- like IgGs (L-IgG) purified from normal serum. In intact brain, antigen ic determinants for these IgG were restricted to some blood vessel end othelial cells. By contrast, during the inflammatory reaction followin g a surgical injury, these determinants were detected at the cell surf ace of different cell types, within and near the lesion site. The cell s reacting with L-IgG consisted of endothelial cell, mature astrocytes , activated microglial and ependymal cells.