ANTIOXIDATION OF HUMAN LOW-DENSITY-LIPOPROTEIN BY MORIN HYDRATE

Oxidative modification of low density lipoprotein (LDL) has been sugge sted to be a risk factor for the development of atherosclerosis. Agent s which can protect LDL from oxidation may be useful in preventing ath erogenesis. Here, we found that morin hydrate, at 100 mu M concentrati on, effectively inhibits Cu2+- induced oxidation of LDL. The oxidation of LDL was assessed by agarose gel electrophoresis. This was further studied by measuring the increased values of the malondialdehyde equiv alents and the decreased numbers of reactive amino groups on oxidized LDL. Trolox, at equimolar concentrations, exhibit similar effects in p reventing oxidation of LDL.