ENZYMATIC MECHANISMS OF RESISTANCE TO AMI NOGLYCOSIDE ANTIBIOTICS IN GRAM-NEGATIVE BACILLI FROM CHILEAN HOSPITALS

Authors
DELSOLAR E GARCIA A BELLO H DOMINGUEZ M GONZALEZ G ZEMELMAN R
Citation
E. Delsolar et al., ENZYMATIC MECHANISMS OF RESISTANCE TO AMI NOGLYCOSIDE ANTIBIOTICS IN GRAM-NEGATIVE BACILLI FROM CHILEAN HOSPITALS, Revista Medica de Chile, 123(3), 1995, pp. 293-297
Citations number
20
Categorie Soggetti
Medicine, General & Internal
Journal title
Revista Medica de Chile → ACNP
ISSN journal
00349887
Volume
123
Issue
3
Year of publication
1995
Pages
293 - 297
Database
ISI
SICI code
0034-9887(1995)123:3<293:EMORTA>2.0.ZU;2-T
Abstract
The presence of aminoglycoside modifying enzymes (AMEs) has been inves tigated, by an agar diffusion method, in 344 strains of aminoglycoside -resistant Gram negative bacilli isolated in different Chilean hospita ls. Most of the strains exhibited a combination of enzymatic mechanism of resistance, but two acetylating (AAC(3)II and AAC(6')I) and one ph osphorylating (APH(3')I) enzymes were the main mechanism detected in t he strains. A significant increase in the frecuency of strains produci ng AAC(6')I, possibly due to wide use of amikacin, has been found when results were compared with those of a report published in 1985.