BENEFICIAL-EFFECTS OF H290 51, A NEW LIPID-PEROXIDATION INHIBITOR, ONFUNCTIONAL RECOVERY AFTER ISCHEMIA AND REPERFUSION IN ISOLATED COLD-ARRESTED RAT HEARTS/
Qd. Wang et al., BENEFICIAL-EFFECTS OF H290 51, A NEW LIPID-PEROXIDATION INHIBITOR, ONFUNCTIONAL RECOVERY AFTER ISCHEMIA AND REPERFUSION IN ISOLATED COLD-ARRESTED RAT HEARTS/, Journal of cardiovascular pharmacology, 25(6), 1995, pp. 924-929
Lipid peroxidation is one of the major mechanisms involved in free rad
ical-mediated postischemic myocardial injury. Ln the present study, a
newly synthetized lipid peroxidation inhibitor H290/51 7metyl-9-methox
y-5,5a,b,10b-tetrahydroindeno(2,1-6 indole)] was evaluated for its eff
ects on myocardial functional recovery during reperfusion after 30-min
global ischemia in isolated cold-arrested rat hearts. Administration
of 200 and 800 nM H290/51 at initiation of global ischemia markedly im
proved the functional recovery, whereas 50 nM H290/51 had no significa
nt effects. The percent recovery of cardiac output (CO), left ventricu
lar developed pressure (LVDP), and LVdP/dt(max) at the end of the 30-m
in reperfusion period in the working mode was much higher in the group
s receiving 200 and 800 nM H290/51 than that in vehicle group (CO 73 /- 5 and 60 +/- 5 vs. 23 +/- 7%; LVDP 79 +/- 5 and 73 +/- 8 vs. 43 +/-
10%; LV dP/dt(max) 78 +/- 5 and 69 +/- 4 vs. 45 +/- 10%). The indenoi
ndole compound H290/51 51 reduced ischemia/reperfusion-induced cardiac
dysfunction.