SEQUENCES DERIVED FROM THE HIGHLY ANTIGENIC VP1 REGION-140 TO REGION-160 OF FOOT-AND-MOUTH-DISEASE VIRUS DO NOT PRIME FOR A BOVINE T-CELL RESPONSE AGAINST INTACT VIRUS

Although VP1 region 140 to 160 of foot-and-mouth disease virus (FMDV) is able to elicit neutralizing antibody in cattle, the protection agai nst virus challenge that is conferred by peptide immunization is often poor. Here, we show that bovine T cells primed with peptides derived from this region generally show no reactivity to intact FMDV. In contr ast, T-cell epitope VP4[20-34] is able to prime for a virus specific r esponse.