TYROSINE PROTEIN-KINASE ACTIVITY IN MAMMA RY-CARCINOMA, BENIGN LESIONS AND NORMAL MAMMARY TISSUE

Authors
PIERART J ONATE E KLAASSEN R CID L GUTIERREZ S TALBOT E ROSS E ZAMBRANO C BURMEISTER R PUCHI M IMSCHENETZKY M
Citation
J. Pierart et al., TYROSINE PROTEIN-KINASE ACTIVITY IN MAMMA RY-CARCINOMA, BENIGN LESIONS AND NORMAL MAMMARY TISSUE, Revista Medica de Chile, 123(2), 1995, pp. 165-175
Citations number
32
Categorie Soggetti
Medicine, General & Internal
Journal title
Revista Medica de Chile → ACNP
ISSN journal
00349887
Volume
123
Issue
2
Year of publication
1995
Pages
165 - 175
Database
ISI
SICI code
0034-9887(1995)123:2<165:TPAIMR>2.0.ZU;2-B
Abstract
Tyrosine proteln kinase (TPK) activity is associated to malignant cell ullar transformation. This work compares TPK activity in 27 surgical b iopsy samples of mammary carcinoma, 10 samples of fibroadenomas, 13 sa mples of fibrocystic breast disease and 27 samples of normal mammary t issue. TPK activity was determined in tissue homogenates using (Val(5) ) angiotensin II as exogenous substrate. In samples of mammary carcino ma TPK activity was 33.86 +/- 32.98 pmol P32/mg protein/30 min. This v alue was significantly higher that those observed in fibrocystic disea se (3.92 +/- 2.35), fibroadenomas (13.86 +/- 10.9) and normal tissue ( 3.56 +/- 3.02).