LIPID-PEROXIDATION IN LUNG OF RAT STRESSED BY IMMOBILIZATION - EFFECTS OF VITAMIN-E SUPPLEMENTATION

This study was carried out to examine the possibility of initiation of lipid peroxidation in the lung of Wistar albino male rats stressed by immobilization. The effects of vitamin E supplementation were also in vestigated. We found that immobilization of rats with normal pulmonary content of vitamin E caused lipid peroxidation in the lung. Decrease of the lung content of unsaturated fatty acids and vitamin E was also established. The immobilization-induced changes of all of these parame ters were significantly inhibited by vitamin E injection (100 mg/kg bo dy weight) for 7 days. A possible sequence of events leading to the in itiation of lipid peroxidation and lung cell membrane damage in rats s tressed by immobilization is discussed.