STRUCTURAL ORGANIZATION AND MAPPING OF THE HUMAN TCF11 GENE

We recently cloned human cDNA representing several mRNA isoforms of hu man TCF11, a transcription factor of the basic-region, leucine-zipper (bZIP) family located on chromosome 17q22 as well as a genomic clone o f this gene. We have now determined the complete genomic organization of the TCF11 gene, which consists of 9 exons distributed over 15 kb of genomic DNA. Pulsed-field gel electrophoresis was used to construct a physical map around TCF11, to characterize a 450-kb YAC clone that co ntains the gene, and to link TCF11 physically to BTR, a marker on chro mosome 17. (C) 1995 Academic Press, Inc.