RELATIVE EFFICIENCIES OF CHI(2) MODELS OF RECOMBINATION FOR EXCLUSIONMAPPING AND GENE ORDERING

In multilocus linkage analysis, it is common to assume chiasma interfe rence is absent. While this assumption provides mathematical tractabil ity, there is substantial biological evidence contradicting it, partic ularly when the loci are closely spaced. The chi(2) class of recombina tion models, recently described by Foss et al. (Genetics 133: 681-691, 1993), has a plausible biological basis and provides a dramatically i mproved fit over virtually all other models currently in use. Here, a simulation study is performed to assess the relative efficiency of a n o interference model analysis to an analysis with a chi(2) model which allows for interference. The results presented show that analysis wit h the no interference model is inefficient in the presence of interfer ence. (C) 1995 Academic Press, Inc.