41 KILOBASES OF ANALYZED SEQUENCE FROM THE PSEUDOAUTOSOMAL AND SEX-DETERMINING REGIONS OF THE SHORT ARM OF THE HUMAN Y-CHROMOSOME

Determination of 41.2 kb of Y chromosome genomic sequence has been mad e from a cosmid that spans the Yp pseudoautosomal boundary and include s 18.5 kb of sequence from the patient-defined sex-determining region of the Y chromosome. An AceDB database of the sequence and the analysi s data have been produced as a resource for studies of the evolution a nd population genetics of the Y chromosome. Comparison of the 18.5 kb from the sex determining region to the sex determining region of mouse does not locate any areas of similarity outside SRY/Sry. Indeed, no c oding regions other than those previously reported can be detected any where in the 41 kb. The Y-specific and pseudoautosomal portions of thi s sequence have different repeat sequence and GC contents: this may ha ve relevance both to the events defining the pseudoautosomal boundary and to the course of sequence evolution in the absence of recombinatio n. (C) 1995 Academic Press, Inc.