MAPPING OF THE GENE FOR THE MEL(1A)-MELATONIN RECEPTOR TO HUMAN-CHROMOSOME-4 (MTNR1A) AND MOUSE CHROMOSOME-8 (MTNR1A)

Authors
SLAUGENHAUPT SA ROCA AL LIEBERT CB ALTHERR MR GUSELLA JF REPPERT SM
Citation
Sa. Slaugenhaupt et al., MAPPING OF THE GENE FOR THE MEL(1A)-MELATONIN RECEPTOR TO HUMAN-CHROMOSOME-4 (MTNR1A) AND MOUSE CHROMOSOME-8 (MTNR1A), Genomics, 27(2), 1995, pp. 355-357
Citations number
14
Categorie Soggetti
Genetics & Heredity
Journal title
Genomics → ACNP
ISSN journal
08887543
Volume
27
Issue
2
Year of publication
1995
Pages
355 - 357
Database
ISI
SICI code
0888-7543(1995)27:2<355:MOTGFT>2.0.ZU;2-C
Abstract
The pineal hormone melatonin elicits potent circadian and reproductive effects in mammals. We report the chromosomal location of the gene fo r the Mel(1a)-melatonin receptor that likely mediates these circadian and reproductive actions, PCR analysis of human-rodent somatic cell hy brids showed that the receptor gene (MTNR1A) maps to human chromosome 4q35.1. An interspecific backcross analysis revealed that the mouse ge ne (Mtnr1a) maps to the proximal portion of chromosome 8. These loci m ay be involved in genetically based circadian and neuroendocrine disor ders. (C) 1995 Academic Press, Inc.