TRABECULECTOMY WITH LOW CONCENTRATION OF MITOMYCIN (0.2 MG ML FOR 1 MINUTE) - INDEPENDENT EVALUATION OF A RETROSPECTIVE NONRANDOMIZED PILOT-STUDY/

Citation
Dj. Annen et J. Sturmer, TRABECULECTOMY WITH LOW CONCENTRATION OF MITOMYCIN (0.2 MG ML FOR 1 MINUTE) - INDEPENDENT EVALUATION OF A RETROSPECTIVE NONRANDOMIZED PILOT-STUDY/, Klinische Monatsblatter fur Augenheilkunde, 206(5), 1995, pp. 300-302
Citations number
7
Categorie Soggetti
Ophthalmology
Journal title
Klinische Monatsblatter fur Augenheilkunde
ISSN journal
00232165 → ACNP
Volume
206
Issue
5
Year of publication
1995
Pages
300 - 302
Database
ISI
SICI code
0023-2165(1995)206:5<300:TWLCOM>2.0.ZU;2-X
Abstract
Background The application of anti fibroses agents during glaucoma sur gery leads to more satisfactory results with lower i.o. pressure, yet eliciting complications in wound healing, avascular filtering blebs an d frequent chronic hypotonias. In patients with lower risk for failure a reduction of concentration and application time of Mitomycin C shou ld minimise side effects while maintaining the beneficial effect of lo wer intraocular pressure. Patients and Methods 34 eyes of 32 patients (age 72+/-8) underwent trabeculectomy (14 combined with phacoemulsific ation and implantation of a foldable posterior chamber lens). During f iltering surgery, Mitomycin C (0.2 mg/ml for 1 min) was applied after preparation of the scleral flap. An 11.5+/-5.0 (3-21), month followup, 30 (34) eyes (88.2%) had an i.o. pressure of less than or equal to 21 mm Hg (14.0+/-4.3 mm Hg at the last control) without additional glauc oma medications. Results The majority of filtering blebs (30/34; 88.2% ) were well vascularised, often showing polycystic degenerations near the limbus. Only 3 eyes developed an avascular filtering bleb. No pers isting leaks were observed and only 2 of 34 eyes (5.9%) developed shor t transient hypotonia (IOP < 6 mm Hg). Conclusions Adjunctive treatmen t with low concentration of Mitomycin C during filtering surgery resul ts in good i.o. pressure with little risk of avascular bleb developmen t. A prospective, randomised trial is required to assess the safety an d efficacy of adjuvantive Mitomycin C treatment in low risk filtering surgery.