COMPARATIVE-STUDY OF 0,2 MG ML MITOMYCIN- C IN TRABECULECTOMIES - 2.5OR 5 MINUTES/

Background To analyse the inocuity and the incidence of complications of a 0.2 mg/ml solution of Mitomycin C (M.M.C.), for two application t ime, 2.5 or 5 minutes. Methods 110 trabeculectomies were realised in 9 9 patients; they were high-risk (HR) patients in 66 cases, and low-ris k (LR) patients in 44 cases. M.M.C. was used for 2.5 minutes in 44 cas es (20 HR patients, 24 LR patients), and for 5 minutes in 66 cases (46 HR patients, 20 LR patients). Results In both groups HR and LR, there is no significant difference on the pressure lowering whether the 0.2 mg/ml solution of M.M.C. is used during 2.5 minutes or 5 minutes (Stu dent t-test at 6 months: HR: p=0.224; FR: p=0.542). For the early and late complication in the HR group,there is no significant difference w hether M.M.C. is used 2.5 or 5 minutes. In the LR group, there is a si gnificant difference for hypothalamy (p=0.035) and choroidal detatchme nt (p=0.027). In this LR group, there is no significant difference in the late complications. Conclusions A 0.2 mg/ml solution of M.M.C., wh en indicated, may be used as well in the HR and LR group during 2'30'' . In the HR group, if there are several risk factors, we propose to ad apt the application time between 2.5 and 5 minutes, and increase it by 1/2 or 1 minute for each risk factor.