A total of 100 consecutive patients with perforated duodenal or juxtap
yloric ulcers were treated by: laparotomy and omental patch repair (gr
oup 1, n = 44); laparoscopic suture patch repair (group 2, n = 35); an
d laparoscopic fib;in glue repair (group 3, n = 21). The three groups
were comparable in Acute Physiology And Chronic Health Evaluation II s
core and in other known operative risk factors such as shock on admiss
ion, delayed presentation and associated underlying medical illness. O
perative mortality and morbidity data were identical in all groups. Th
e mean operating time was 52.1, 101.3 and 61.1 min respectively in the
three groups (group 1 versus group 2, group 2 versus group 3, and gro
up 1 versus groups 2 and 3 combined, P < 0.001). The median number of
doses of analgesia required after operation was 4, 3 and 1 respectivel
y (group 1 versus groups 2 and 3, P < 0.05). Conversion to laparotomy
was necessary in six patients in group 2 and in one in group 3 (P not
significant). The median hospital stay was 5 days in all three groups.
Patients who underwent laparoscopic repair of perforated peptic ulcer
required fewer postoperative doses of analgesia than those who had op
en repair. Laparoscopic glue repair has the additional advantage over
laparoscopic suture of being technically simpler; it also takes less t
ime to perform.