Y. Komata et al., ACCUMULATION OF LAURIC ACID IN SKIN AS AN ENHANCER FOR THE PERCUTANEOUS-ABSORPTION OF THIAMINE DISULFIDE, Biological & pharmaceutical bulletin, 18(5), 1995, pp. 791-793
The permeation and accumulation of lauric acid (12:0) in rat skin as a
n enhancer for the percutaneous absorption of thiamine disulfide (TDS)
, using propylene glycol as a vehicle, were determined in vitro. 12:0
barely permeated through skin, and accumulated in skin. The accumulate
d amount increased with increasing concentrations in the vehicle (1-20
%). The proportion of the accumulation to total dose was highest at a
dose of 5%. A positive relationship was found between the accumulated
amount of TDS and 12:0. It was suggested that the penetration of 12:0
into skin contributes to the enhanced partition of TDS to skin.