RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM ANALYSIS RULES OUT CROSS-INFECTION AMONG RENAL PATIENTS WITH TUBERCULOSIS

Authors
BENDALL RP DROBNIEWSKI FA JAYASENA SD NYE PM UTTLEY AHC SCOTT GM
Citation
Rp. Bendall et al., RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM ANALYSIS RULES OUT CROSS-INFECTION AMONG RENAL PATIENTS WITH TUBERCULOSIS, The Journal of hospital infection, 30(1), 1995, pp. 51-56
Citations number
8
Categorie Soggetti
Infectious Diseases
Journal title
The Journal of hospital infection → ACNP
ISSN journal
01956701
Volume
30
Issue
1
Year of publication
1995
Pages
51 - 56
Database
ISI
SICI code
0195-6701(1995)30:1<51:RAROC>2.0.ZU;2-4
Abstract
A cluster of five cases of tuberculosis occurred on a renal unit in 19 93. The initial impression was that this was an outbreak, and cross-in fection was suspected. Restriction fragment length polymorphism analys is was carried out on the strains of Mycobacterium tuberculosis isolat ed from these cases, using a DNA probe directed against the insertion sequence IS6110. DNA fingerprints obtained by this method differed for all the strains tested, ruling out cross-infection as a cause of the outbreak. This technique is a useful adjunct to standard epidemiologic al investigations in outbreaks of tuberculosis.