PHYSICOCHEMICAL CHARACTERIZATION OF A NEW RESPIRABLE FORM OF NEDOCROMIL

Elongated, respirable particles of nedocromil were prepared by its cry stallization from N-methyl-2-pyrrolidone (NMP) obtained from an aqueou s solution of its sodium salt by precipitation with hydrochloric acid. Aerosols of these particles were recently generated and characterized for their aerodynamic properties (Chan, H.-K.; Gonda, I. J. Aerosol M ed. 1993, 6, 241-249). This paper reports the physicochemical properti es of the solid form of nedocromil as characterized by polarizing opti cal and scanning electron microscopies, thermal analysis (DSC, TGA), X -ray powder diffraction, water vapor adsorption isotherms, mass spectr ometry, solid state Fourier transform IR and solution H-1-NMR spectros copies.