STEREOCHEMICAL AND BIOCHEMICAL ASPECTS OF ORGANOBORON(LLL) COMPOUNDS OF HYDRAZONECARBOXAMIDES AND HYDRAZONECARBOTHIOAMIDES

Hydrazonecarboxamides and hydrazonecarbothioamides and their derivativ es have important pharmacodynamic significance. In the search for bett er fungicides and bactericides, organoboron(III) compounds derived fro m these ligands were screened for their antifungal and antibacterial a ctivities. The heterocyclic aldimines were prepared by the condensatio n of (2-furanyl)methanal, (2-thienyl)methanal, (2-pyridinyl)methanal, (1H-indol-3-yl)methanal or 3-phenyl-2-propenal with hydrazinecarboxami de or hydrazinecarbothioamide. Unimolar and bimolar reactions between phenyldihydroxyborane and these ligands have produced PhB(OH)(NO), PhB (NO)(2), PhB(OH)(NS) and PhB(NS)(2) types of biologically active compo unds. Structural assignment has been made through UV, IR and NMR (H-1, B-11 and C-13) spectroscopy. TGA and XRD of a representative compound have also been carried out. The compounds were tested in vitro agains t a number of fungal and bacterial strains and were found to possess m oderate to good toxicity.