Ticlopidine, a platelet aggregation inhibitor, has been approved to de
crease the risk of thrombotic stroke. We describe a 75-year-old white
woman who developed acute renal failure 10 days after initiating ticlo
pidine therapy. A renal biopsy revealed interstitial infiltrates conta
ining lymphocytes and eosinophils. To our knowledge this is the first
report of ticlopidine-induced acute interstitial nephritis. (C) 1995 b
y the National Kidney Foundation, Inc.