Rj. Stewart et Pa. Marsden, BIOLOGIC CONTROL OF THE TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 SIGNALING CASCADE, American journal of kidney diseases, 25(6), 1995, pp. 954-966
It is clear that activation of the proinflammatory cytokine cascade is
both the cause and the consequence of renal injury, Recently, it has
been appreciated that a rich network of signaling pathways contributes
to modulation of tumor necrosis factor-alpha (TNF) and interleukin-1
(IL-1) bioactivity, both in vitro and in vivo. Insight into the checks
and balances that intervene or temper endogenous cytokine effector me
chanisms has arisen from an explosion of new information on the cell b
iology of proinflammatory cytokines. Novel mechanisms of cytokine regu
lation are currently being described and hold promise for therapeutic
potential: soluble cytokine receptors, endogenous receptor antagonists
, and anti-inflammatory cytokines such as IL-4, IL-10, and IL-13. (C)
1995 by the National Kidney Foundation, Inc.