La. Bristol et al., INHIBITION OF CD26 ENZYME-ACTIVITY WITH PRO-BOROPRO STIMULATES RAT GRANULOCYTE-MACROPHAGE COLONY FORMATION AND THYMOCYTE PROLIFERATION IN-VITRO, Blood, 85(12), 1995, pp. 3602-3609
CD26 dipeptidyl peptidase (DPPIV) is involved in the regulation of pro
liferation of some hematopoietic and T-lineage cells. Here, we show th
at Pro-boropro a potent inhibitor of DPP activity has a costimulating
effect in hematopoietic colony assays for macrophage and, to a lesser
extent, for granulocyte colonies and has a stimulating effect in organ
cultures of immature thymocytes. Based on these and other evidences,
we propose that the mechanism by which CD26 regulates proliferation is
associated with its DPP activity. (C) 1995 by The American Society of
Hematology.