PHASE-BEHAVIOR OF NOVEL PHOSPHOLIPID ANALOGS

The phase behaviour of phospholipid analogues containing a phosphorami de moiety was investigated using polarized light microscopy. A complex liquid-crystalline polymorphism consisting of lamellar, and normal to pology hexagonal and intermediate phases was observed and found to dep end on the structure of the phosphoramide headgroup and its methylatio n. In addition, a lower consolute phase boundary in the micellar solut ion part of the phase diagram was observed in some systems. The aggreg ation behaviour of these novel amphiphiles was compared with that of q uaternary ammonium and oligo-ethylene oxide amphiphiles.