DETERMINATION OF LIPASE SPECIFICITIES THROUGH THE USE OF CHIRAL TRIGLYCERIDES AND THEIR RACEMICS

Authors
VILLENEUVE P PINA M MONTET D GRAILLE J
Citation
P. Villeneuve et al., DETERMINATION OF LIPASE SPECIFICITIES THROUGH THE USE OF CHIRAL TRIGLYCERIDES AND THEIR RACEMICS, Chemistry and physics of lipids, 76(1), 1995, pp. 109-113
Citations number
15
Categorie Soggetti
Biology
Journal title
Chemistry and physics of lipids → ACNP
ISSN journal
00093084
Volume
76
Issue
1
Year of publication
1995
Pages
109 - 113
Database
ISI
SICI code
0009-3084(1995)76:1<109:DOLSTT>2.0.ZU;2-C
Abstract
The previously published synthesis of defined chiral triglycerides has been extended to the synthesis of their racemics. The combined use of the chiral-racemic pair of a triglyceride can now be used to accurate ly define the effective specificity of a large number of lipases. As a n example, we confirm unambiguously in this paper, the sn3 stereospeci ficity for the rabbit gastric lipase, the short chain typoselectivity for the Candida antartica lipase and the sn1 stereospecificity for the Pseudomonas aeruginosa lipase.