S. Watano et al., MODELING AND SIMULATION OF DRUG-RELEASE FROM GRANULE COATED WITH AN AQUEOUS-BASED SYSTEM OF ACRYLIC COPOLYMER, Chemical and Pharmaceutical Bulletin, 43(5), 1995, pp. 877-880
In a previous paper, [Watano et al., Chem. Pharm. Bull., 42, 2338 (199
4)], we proposed a simple model which could be used to analyze data of
controlled release of a water-soluble drug from spherical particles c
oated with an aqueous-based system of acrylic copolymer by a tumbling
fluidized bed process. The model predicted that the fractional release
of drug was related to exponential of release time, and drug release
data of several samples prepared with various levels of operational mo
isture content were studied to determine the effect of this content on
film thickness and drug permeability. In this study, to confirm the m
ethod's validity, we simulated the drug release rate at various moistu
re content and coating levels using the proposed model. The simulated
results were compared with the experimental data to evaluate the accur
acy of the model. The mechanism of aqueous coating was also described
using the simulated results.