A NOVEL HEXAHYDRODIBENZOFURAN DERIVATIVE WITH POTENT INHIBITORY ACTIVITY ON MELANIN BIOSYNTHESIS OF CULTURED B-16 MELANOMA-CELLS FROM LINDERA-UMBELLATA BARK

Authors
MIMAKI Y KAMEYAMA A SASHIDA Y MIYATA Y FUJII A
Citation
Y. Mimaki et al., A NOVEL HEXAHYDRODIBENZOFURAN DERIVATIVE WITH POTENT INHIBITORY ACTIVITY ON MELANIN BIOSYNTHESIS OF CULTURED B-16 MELANOMA-CELLS FROM LINDERA-UMBELLATA BARK, Chemical and Pharmaceutical Bulletin, 43(5), 1995, pp. 893-895
Citations number
1
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
5
Year of publication
1995
Pages
893 - 895
Database
ISI
SICI code
0009-2363(1995)43:5<893:ANHDWP>2.0.ZU;2-Q
Abstract
A novel cinnamoyl-hexahydrodibenzofuran derivative (1) was isolated fr om the bark of Lindera umbellata. The structure was determined by exte nsive spectroscopic analysis to be -methylethyl)-5a,6,7,8,9,9a-hexahyd rodibenzofuran. Compound 1 showed potent inhibitory activity on melani n biosynthesis of cultured B-16 melanoma cells without causing any cyt otoxicity in the cultured cells or skin irritation in guinea pig.