THE INFLUENCE OF FIBRINOGEN CONCENTRATION ON THE DEVELOPMENT OF VEIN GRAFT STENOSES

Objective: The aim of this study was to identify factors associated wi th the development of graft stenoses in the first year after bypass. D esign and setting: Between January 1992 and April 1943, 75 consecutive patients undergoing distal vein bypass surgery were entered into a gr aft surveillance programme at Charing Cross Hospital. The grafts (n = 79) were surveyed by colour flow Doppler ultrasonography at 7 days, 3, 6, 9 and 12 months and the site of stenoses (> 50%) recorded. Positio n of the distal anastomosis, graft type (in situ or reverse) and clini cal history were recorded. At the 3-month surveillance a blood sample was taken for the estimation of smoking markers, lipids and fibrinogen . Results: The site of the distal anastomosis was to the supragenicula te popliteal in nine, infrageniculate popliteal in 32 and tibio/perone al vessels in 38 cases. In the first month following bypass there were six deaths, giving a 30 day mortality of 7.5%, three patients were lo st to follow up, seven grafts occluded three were replaced by PTFE, fo ur patients underwent amputation and one patient had a redo vein graft . In the remaining grafts 20/63 (32%) developed stenoses within the fi rst year after bypass. The development of a graft stenosis was not ass ociated with sex, diabetic status, site of distal anastomosis, graft t ype or serum lipids. Multiple regression analysis identified only one factor associated significantly with the development of vein graft ste nosis: fibrinogen concentration (p = 0.003). Life table analysis showe d that after 1 year only 46% of grafts remained free of stenoses in pa tients with above median fibrinogen concentrations compared with 84% o f grafts in patients with below median fibrinogen concentrations, p = 0.009. Conclusions: Increased plasma fibrinogen concentration is a pot ent risk factor for the development of vein graft stenosis. These resu lts prompt consideration of the role of fibrinogen in stimulating smoo th muscle cell proliferation in the stenotic lesion.