ANTITUMOR EFFECTS OF DOXORUBICIN HYDROCHLORIDE (DOX) AND BUTHIONINE SULFOXIMINE (BSO)-HYDROXYAPATITE (HAP) COMPLEX ON TRANSPLANTED TUMORS IN-VIVO

Authors
IMAMURA M SEKI T KUNIEDA K WAKABAYASHI M INOUE K OBIYA Y HARADA K
Citation
M. Imamura et al., ANTITUMOR EFFECTS OF DOXORUBICIN HYDROCHLORIDE (DOX) AND BUTHIONINE SULFOXIMINE (BSO)-HYDROXYAPATITE (HAP) COMPLEX ON TRANSPLANTED TUMORS IN-VIVO, Oncology Reports, 2(4), 1995, pp. 509-511
Citations number
9
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
2
Issue
4
Year of publication
1995
Pages
509 - 511
Database
ISI
SICI code
1021-335X(1995)2:4<509:AEODH(>2.0.ZU;2-7
Abstract
We prepared hydroxyapatite (HAP) beads containing doxorubicin hydrochl oride (DOX) and buthionine sulfoximine (BSO), as a DOX and BSO-HAP com plex. When the complex was implanted into mice bearing sarcoma 180 tum or, the antitumor effect of the complex was intensified 1.5-fold, as a ssessed using tumor volume, on day 27 as compared with that of a compl ex of DOX-HAP only. Therefore, we concluded that the antitumor effect of the DOX and BSO-HAP complex was increased through depletion of the intracellular radical scavenger glutathione (GSH) by released BSO and subsequently free radicals produced by released DOX.