SULFASALAZINE-INDUCED LUPUS IN PSORIATIC-ARTHRITIS

Lupus syndromes have been described in rheumatoid arthritis and inflam matory bowel diseases treated with sulphasalazine. We describe two cas es of lupus with clinical and serological disease, developing in seron egative, immunologically nude psoriatic arthritis following sulphasala zine treatment. On cessation of sulphasalazine the clinical and serolo gic features of lupus disappeared. This suggests that the lupus syndro me was induced by sulphasalazine rather than unmasked by it.