STRUCTURES OF PHOSPHOLIPASE-A(2) INHIBITORS, ERGOPHILONES-A AND ERGOPHILONES-B

Authors
HYODO S FUJITA KI KASUYA O TAKAHASHI I UZAWA J KOSHINO H
Citation
S. Hyodo et al., STRUCTURES OF PHOSPHOLIPASE-A(2) INHIBITORS, ERGOPHILONES-A AND ERGOPHILONES-B, Tetrahedron, 51(24), 1995, pp. 6717-6724
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
24
Year of publication
1995
Pages
6717 - 6724
Database
ISI
SICI code
0040-4020(1995)51:24<6717:SOPIEA>2.0.ZU;2-Y
Abstract
Two novel fungal metabolites, ergophilones A and B, were isolated as p hospholipase A, inhibitors. The planar structures were determined on t he bases of UV, MS and NMR analyses, and the stereochemistries were el ucidated by the NOE experiments, coupling constant values and CD analy ses. Ergophilones A and B contain three structural moieties, i.e., erg ostane skeleton, azaphilone chromophore and o-orsellinic acid, respect ively.