APPLICATION OF TERMINAL BIFUNCTIONALIZATI ON OF OLIGOETHYLENIMINE TO POLYMER SYNTHESIS - SYNTHESIS OF MODIFIED NYLON-6,6 VIA TERPOLYCONDENSATION AND PT(II) COMPLEX OF HOMOPOLYAMIDE

Multi-functional pentaethylenehexamine was terminally bifunctionalized via the five-membered ring protection method. The bifunctionalized ol igoamine was employed as a monomer in polycondensation reaction in ord er to examine some possibilities in application of the oligoethylenimi ne-incoporated polymers. First, introduction of the oligoamine units i n the polymer main drain leads to chemical modification of nylon-6,6 t hrough terpolymerization of adipoyl dichloride with hexamethylenediami ne and the protected oligoamine. The resulted copolyamides after depro tection were found to be water-soluble when the molar ratio of hexamet hylenediamine to the protected oligoamine was lower than 0.5. Higher r atio yielded water-swellable polyamides. The second example wits the c helate-forming property of the oligoethylenimine-incorporated polyamid e. The property was proved by reacting a homopolyamide with K2PtCl4 to obtain water-soluble polymer-Pt(II) complexes. The third one was the biological test of the latter water-soluble Pt-complex, by which nonto xicity for mouse was shown. Further biological tests were also carried out to obtain basic information on its anti-cancer activity.