ANTIULCER ACTION AND TOXICITY OF STYRAX-CAMPORUM AND CAESALPINIA-FERREA

Oral administration of Styrax camporum Pohl and Caesalpinia ferrea Mar tius stem extracts, atropine, and cimetidine, during 15 days, decrease d the ulceration size, gastric secretion volume, and increased collage n fibre number of chronic ulcer induced by acetic acid in rats. The pH increased and the concentration of hydrochloric acid decreased after administration of atropine and cimetidine. The ethyl acetate fraction, obtained by chromatography from Styrax camporum Pohl extracts, showed antiulcer activity. The subchronic toxicity was studied during 30 day s, through weight variation, water and food consumption and spleen, lu ng, kidney and liver relative weights. No difference to the control-lo t was observed.