SQUAMOUS-CELL CARCINOMA OF THE BREAST AFTER AUGMENTATION WITH LIQUID SILICONE INJECTION

Squamous cell carcinoma of the breast is an extremely rare neoplasm. A pproximately 50 cases have been reported in the English literature sin ce 1917, The pathogenesis of squamous cell carcinoma of the breast is puzzling because epithelial elements are not normally identified in br east tissue, It has been suggested that epithelial cells are derived f rom epidermoid cysts deposited during early embryological development, from metaplastic transformation of ductal cells, or after trauma or s urgical manipulation, Although no evidence has been published to suppo rt a causal relationship between liquid Silicone:induced mastopathy an d breast carcinoma, squamous cell cancers are known to arise in the se tting of prolonged inflammation often seen after liquid silicone injec tion, This case of primary squamous cell carcinoma of the breast, aris ing 25 years after augmentation with liquid silicone injections, occur red in a 70-year-old patient with silicone-induced mastopathy.