SYNTHESIS, PROPERTIES, STRUCTURE AND BIOACTIVITY IN-VITRO OF MONONUCLEAR COMPLEXES OF MANGANESE AND NICKEL WITH HYDROXYETHYLTRIBENZIMIDAZOLYLMETHYL ETHYLENE DIAMINE

Six novel mononuclear complexes, MnCI(2)L . H2O, Mn(SCN)(2)L . 2H(2)O, Mn(ClO2)(2)L . 2H(2)O, NiCl(2)L . 2H(2)O, Ni(SCN)(2)L . H2O, Ni(ClO4) (2)L (L = N-hydroxyethyl-N,N',N'-tribenzimidazolylmethyl ethylene diam ine), have been synthesized and characterized. The UV-visible spectra of nickel complexes reveal that L is a weak field ligand. The ESR spec tra indicate the asymmetric electronic environment of the manganese io n in its complex. The crystal and molecular structures of Ni(SCN)(2)L . H2O were determined by X-ray diffraction analysis. The nickel ions h ave distorted octahedral symmetry. The preliminary results of bioassay of the complexes showed that monomanganeses have antitumour activitie s in vitro.