BINUCLEAR COPPER(II) COMPLEXES OF 2-HYDROXYACETOPHENONE N-4-SUBSTITUTED THIOSEMICARBAZONES

Binuclear copper(II) complexes with eight different 2-hydroxyacetophen one N-4-substituted thiosemicarbazones have been prepared and characte rized. IR, electronic, H-1 NMR and ESR spectra of the complexes, as we ll as IR, UV and H-1 NMR spectra of the thiosemicarbonazones, have bee n obtained. The crystal structure for the copper(II) complex of 2-hydr oxyacetophenone 3-hexamethyleneiminylthiosemicarbazone, [Cu(Aphexim)]( 2), has been solved and its structural properties are compared to a re cently reported nickel(II) complex. Both the thiosemicarbazones and th eir copper(II) complexes show no growth inhibitory activity against As pergillus niger, but many have considerable activity against Paecilomy ces variotii. Further, there is a relationship between the antifungal activity and the size of the N-4 substituent for both the thiosemicarb azones and their copper(II) complexes.