SUPEROXIDE-DISMUTASE ACTIVITY OF THE CAPTOPRIL-IRON COMPLEX

Authors
JAY D CUELLA A JAY E
Citation
D. Jay et al., SUPEROXIDE-DISMUTASE ACTIVITY OF THE CAPTOPRIL-IRON COMPLEX, Molecular and cellular biochemistry, 146(1), 1995, pp. 45-47
Citations number
21
Categorie Soggetti
Biology
Journal title
Molecular and cellular biochemistry → ACNP
ISSN journal
03008177
Volume
146
Issue
1
Year of publication
1995
Pages
45 - 47
Database
ISI
SICI code
0300-8177(1995)146:1<45:SAOTCC>2.0.ZU;2-I
Abstract
With an assay that generates superoxide anion radicals without the int ervention of metal ions we investigated the antioxidant properties of captopril, an angiotensin-converting enzyme inhibitor with a sulfhydry l group. Under these conditions, increasing concentrations of the drug were seen not to scavenge O-2(-) directly. However, a combination of captopril and iron could bring about the breakdown of the superoxide a nion; a result that may help to understand the free radical-scavenging properties of captopril.