SPECIES-DIFFERENCES IN 5-HT2A RECEPTORS - CLONED PIG AND RHESUS-MONKEY 5-HT2A RECEPTORS REVEAL CONSERVED TRANSMEMBRANE HOMOLOGY TO THE HUMAN RATHER THAN RAT SEQUENCE

Authors
JOHNSON MP BAEZ M KURSAR JD NELSON DL
Citation
Mp. Johnson et al., SPECIES-DIFFERENCES IN 5-HT2A RECEPTORS - CLONED PIG AND RHESUS-MONKEY 5-HT2A RECEPTORS REVEAL CONSERVED TRANSMEMBRANE HOMOLOGY TO THE HUMAN RATHER THAN RAT SEQUENCE, Biochimica et biophysica acta. Biomembranes, 1236(1), 1995, pp. 201-206
Citations number
17
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1236
Issue
1
Year of publication
1995
Pages
201 - 206
Database
ISI
SICI code
0005-2736(1995)1236:1<201:SI5R-C>2.0.ZU;2-2
Abstract
Pig and rhesus monkey 5-HT2A receptor cDNA clones were isolated. The p ig and rhesus monkey clones encode proteins that share a 94% and 95% h omology, respectively, with the rat 5-HT2A receptor, and a 97% and > 9 9% homology, respectively, with the human 5-HT2A receptor. Within the transmembrane regions of the pig and monkey receptors, the deduced ami no acid shows only three differences compared to that of the rat and a re identical to the human 5-HT2A receptor clone.